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Furthermore, inclusion of a His-tag during expression (for subsequent Ni-nitrilotriacetic acid purification) might alter protein folding and thus binding results (Ledent et al., 1997)

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Safinamide is associated with an increased risk of fractures and falls when used with anxiolytics or antihypertensives due to its hypotensive potential, psychosis when combined with amantadine, and neuropsychiatric adverse events with dopamine agonists